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"We are taking an already transformational approach used for blood cancers and modifying it for use in difficult-to-treat solid cancers," says Shahab Asgharzadeh, lead researcher on a $6 million grant from the California Institute for Regenerative Medicine to treat children and adolescents with recurrent solid tumors.
Asgharzadeh and his team at Children's Hospital Los Angeles have learned, chemotherapy and radiation provide less than a 30% overall survival rate for patients with sarcomas and neuroblastomas, which tend to reoccur in children and young adults after they've received chemo and radiation, per a press release.
That's why the researchers are working on using patients' own immune cells to target and kill the cancer cells instead of using the patient's own cells to do so.
"This CAR T-cell approach enhances the engineered immune cells, so they are not disabled once they enter the solid tumor environment, allowing them to better kill the cancer cells," Asgharzadeh says.
"This therapy offers an alternative to our young patients whose tumors have returned and who currently lack good therapeutic options," he adds.
The team plans to use a method called chimeric TGFB-signaling receptor (CTSR)-enabled anti-B7H3 CAR T-cell therapy
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A customized collection of grant news from foundations and the federal government from around the Web.
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Schneider Electric highlights AI-driven growth, data centre demands, and sustainability ahead of Computex 2025 launch.Schneider Electric discussed AI's rapid growth and its demand for electricity,...more
Mary Ann Wolf is president and executive director of the Public School Forum of North Carolina.Wolf: In local public schools across North Carolina, millions of students receive breakfast and lunch at...more
Oti - the Israeli Autism Association, is advancing the development of children and adults on the autism spectrum.Recent years have witnessed a profound transformation in our understanding of autism...more
COPEMA seeks to mobilise parliamentary support to increase domestic funding and ensure effective implementation of malaria control strategies.The disease accounts for approximately 600,000 deaths...more
MP Tourism Unveils Immersive Zone at KidZania Showcasing the State's Top Attractions.The Madhya Pradesh Tourism Experience Center was officially inaugurated at Kid Zania Mumbai.The initiative is...more
The Momentum Spine App enables radiation-free assessment and provides digital models of the patient's spine.The smartphone app technology starts with parents taking videos of their children at home...more
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