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"We are taking an already transformational approach used for blood cancers and modifying it for use in difficult-to-treat solid cancers," says Shahab Asgharzadeh, lead researcher on a $6 million grant from the California Institute for Regenerative Medicine to treat children and adolescents with recurrent solid tumors.
Asgharzadeh and his team at Children's Hospital Los Angeles have learned, chemotherapy and radiation provide less than a 30% overall survival rate for patients with sarcomas and neuroblastomas, which tend to reoccur in children and young adults after they've received chemo and radiation, per a press release.
That's why the researchers are working on using patients' own immune cells to target and kill the cancer cells instead of using the patient's own cells to do so.
"This CAR T-cell approach enhances the engineered immune cells, so they are not disabled once they enter the solid tumor environment, allowing them to better kill the cancer cells," Asgharzadeh says.
"This therapy offers an alternative to our young patients whose tumors have returned and who currently lack good therapeutic options," he adds.
The team plans to use a method called chimeric TGFB-signaling receptor (CTSR)-enabled anti-B7H3 CAR T-cell therapy
Selected Grant News Headlines
A customized collection of grant news from foundations and the federal government from around the Web.
'Safety, compassion, innovation': Beaufort Memorial honors top staff at Bemmy Awards.The Quality Services department took home the award for Department of the Year at BeaufortMemorial Hospital's...more
This ranking recognizes the leading children's hospitals in the U.S., featuring the top 50 hospitals.Cleveland Clinic Children's placed in all eight pediatric subspecialities: Cardiology and Cardiac...more
Mackinac Policy Conference left early childhood education off this year's agenda.By 2027, make Detroit a city that puts young children and families first, says James Ribbron, executive director of...more
Investing in tech to help children and communities thrive | Takeda Stories.How our Global CSR Program helped empower diverse entrepreneurs to innovate health solutions.29 Digital public goods...more
Greg Bourke is the author of "Gay, Catholic, and American: My Legal Battle for Marriage Equality and Inclusion" Bourke spoke at the Yale School of Management's Social Impact Lab.Bourke's final advice...more
Tesla plans to deploy a small fleet of robotaxis in Austin in the coming weeks.Tesla FSD 13.2.9 will still run a kid down while illegally blowing past a stopped school bus with red lights flashing...more
Awarded funding will support a wide range of activities between now and September 30, 2025.The FCCN initiative, supported by $85,000 in grant funding, will help build and sustain a Family Child Care...more
The Delivering Innovative Vocational Education through Virtual Reality Technology new workforce training program aimed at preparing individuals with disabilities for the program.DIVE-VRT delivers...more
Children are growing up surrounded by screens, apps, and smart devices.Being intentional about tech use goes a long way toward deepening interest in tech and creating meaningful experiences.Creating...more
Safeguarding innovation and trade secrets in American AI leadership Safeguarded innovation andtrade secrets in U.S.AI leadership.Testimony was given before the House Judiciary Subcommittee on Courts,...more
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