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"This project is incredibly innovative and represents a first in the field, raising high hopes for patients with hearing loss."
That from Natalie Loundon, a surgeon who's leading a clinical trial that could lead to a "revolution in the future treatment of hearing loss patients," per a press release from the French biotech company Sensorion.
The drug in question is called Audiogene and works by injecting a copy of the normal otoferlin gene into the inner ear of children with a condition called DFNB9, which results in profound hearing loss.
The usual treatment for this form of hearing loss is a bilateral cochlear implant.
Audiogene works by "correcting the genetic abnormality in the inner ear cells of children with hearing loss and restore inner ear cell function and hearing in these children," says Sensorion CEO Nawal Ouzren.
The drug will be administered under general anesthesia in the same way a cochlear implant is done, so it can be measured precisely and the inner ear structures preserved, the press release notes.
"The launch of the Audiogene clinical trial is a major step forward for deaf children with otoferlin defects and their parents but also brings hope to people with genetic deafness," says Denis Le Squer, executive director of the Fondation Pour l'Audition
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