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"A vast majority of our patients not only responded to the therapy, but they were able to come off their antivirals, which come with extensive side effects," says Michael Keller, the paper's first author and the Translational Research Laboratory director at the Children's National Cell Enhancement and Technologies for Immunotherapy (CETI) program.
In a first-of-its-kind clinical trial, researchers found that therapies made from virus-specific T-cells can effectively treat immunocompromised pediatric patients, far surpassing the current standard of care, according to Nature Communications.
More than 60% of patients in the phase 2 clinical trial led by investigators from Children's National Hospital and Huntsman Cancer Institute responded to the innovative therapy.
This new treatment uses blood from healthy donors to manufacture a highly specialized immune therapy that, when given to immune-compromised patients, prompts their immune system to fight off potentially life-threatening viruses, including cytomegalovirus, Epstein-Barr infections, and adenovirus.
Without this therapy, estimates suggest that less than 30% of patients would recover, using standard protocols.
Children's National is one of a handful of hospitals in the US that uses this approach, and the study includes critically ill patients who are often excluded from research.
Selected Grant News Headlines
A customized collection of grant news from foundations and the federal government from around the Web.
'Safety, compassion, innovation': Beaufort Memorial honors top staff at Bemmy Awards.The Quality Services department took home the award for Department of the Year at BeaufortMemorial Hospital's...more
This ranking recognizes the leading children's hospitals in the U.S., featuring the top 50 hospitals.Cleveland Clinic Children's placed in all eight pediatric subspecialities: Cardiology and Cardiac...more
Mackinac Policy Conference left early childhood education off this year's agenda.By 2027, make Detroit a city that puts young children and families first, says James Ribbron, executive director of...more
Investing in tech to help children and communities thrive | Takeda Stories.How our Global CSR Program helped empower diverse entrepreneurs to innovate health solutions.29 Digital public goods...more
Greg Bourke is the author of "Gay, Catholic, and American: My Legal Battle for Marriage Equality and Inclusion" Bourke spoke at the Yale School of Management's Social Impact Lab.Bourke's final advice...more
Tesla plans to deploy a small fleet of robotaxis in Austin in the coming weeks.Tesla FSD 13.2.9 will still run a kid down while illegally blowing past a stopped school bus with red lights flashing...more
Awarded funding will support a wide range of activities between now and September 30, 2025.The FCCN initiative, supported by $85,000 in grant funding, will help build and sustain a Family Child Care...more
The Delivering Innovative Vocational Education through Virtual Reality Technology new workforce training program aimed at preparing individuals with disabilities for the program.DIVE-VRT delivers...more
Children are growing up surrounded by screens, apps, and smart devices.Being intentional about tech use goes a long way toward deepening interest in tech and creating meaningful experiences.Creating...more
Safeguarding innovation and trade secrets in American AI leadership Safeguarded innovation andtrade secrets in U.S.AI leadership.Testimony was given before the House Judiciary Subcommittee on Courts,...more
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